Contrary to popular belief, obesity doesn’t result as much from laziness and gluttony than it does from genetics. For most overweight people, keeping the pounds off may be significantly harder because they have genes that predispose them to be larger, or cause them to be more addicted to food. Obesity is a growing worldwide epidemic and an estimated 70% of adults in the US are considered overweight or obese. Both conditions are serious health problems because they exponentially raise the risk of diabetes, heart disease, certain types of cancer and heart failure. Unfortunately, many researchers believe that genetics are responsible for at least 50% of all obesity cases. There is not only one gene that influences this, but a multitude of as much as 30 genes.
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VCF , Genotyping Table